File:Olanzapine.svg · Wikimedia Commons · See Wikimedia Commons
olanzapine
Sign in to saveAlso known as Olanzapin, Olanzapinum, 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine, Olanzapina, LY-170053, Zyprexa Zydis
Olanzapine, sold under the brand name Zyprexa among others, is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder. It is also sometimes used off-label in cancer patients for treatment of chemotherapy-induced nausea and vomiting and as an appetite stimulant. For schizophrenia, it can be used for both new-onset disease and long-term maintenance. It is taken by mouth or by injection into a muscle.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 418858405
- Drug.image
- Olanzapine.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200
- Drug.image2
- Olanzapine-from-xtal-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 225
- Drug.tradename
- Zyprexa, others
- Drug.MedlinePlus
- a601213
- Drug.DailyMedID
- Olanzapine
- Drug.pregnancy_AU
- C
- Drug.routes_of_administration
- By mouth, intramuscular
- Drug.class
- Atypical antipsychotic
- Drug.ATC_prefix
- N05
- Drug.ATC_suffix
- AH03
- Drug.legal_AU
- S4
via Wikipedia infobox
Chemical data
- Formula
- C17H20N4S
- Molecular weight
- 312.4 g/mol
- IUPAC name
- 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
- SMILES
- CC1=CC2=C(S1)NC3=CC=CC=C3N=C2N4CCN(CC4)C
- InChIKey
- KVWDHTXUZHCGIO-UHFFFAOYSA-N
- XLogP
- 2.9
- Polar surface area
- 59.1 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
11,795 papers- Olanzapine/Samidorphan: First Approval.Drugs · 2021
- Olanzapine in oncology palliative care.Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti · 2022
- Effectiveness of olanzapine in the treatment of anorexia nervosa: A systematic review and meta-analysis.Brain and behavior · 2022
- Olanzapine-induced cardiomyopathy: A mimicker of obesity cardiomyopathy?Clinical cardiology · 2024
- [Olanzapine].Nihon rinsho. Japanese journal of clinical medicine · 2013
via PubMed
Wikidata facts
- Mass
- 312.1409
Show 5 more facts
- Commons category
- Olanzapine
- chemical formula
- C₁₇H₂₀N₄S
- canonical SMILES
- CC1=CC2=C(S1)NC3=CC=CC=C3N=C2N4CCN(CC4)C
- stylized name
- ZyPREXA
- defined daily dose
- 10
Sources (8)
via Wikidata · CC0
~35 min read
Article
27 sectionsContents
- Medical uses
- Schizophrenia
- Bipolar disorder
- Specific populations
- Pregnancy and lactation
- Elderly
- Adverse effects
- Metabolic effects
- Post-injection delirium/sedation syndrome
- Animal toxicology
- Discontinuation
- Overdose
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Metabolism
- Chemistry
- Chemical synthesis
- Society and culture
- Legal status
- Controversy and litigation
- Brand names
- Dosage forms
- Research
- References
- External links
Olanzapine, sold under the brand name Zyprexa among others, is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder. It is also sometimes used off-label in cancer patients for treatment of chemotherapy-induced nausea and vomiting and as an appetite stimulant. For schizophrenia, it can be used for both new-onset disease and long-term maintenance. It is taken by mouth or by injection into a muscle.
Common side effects include feeling tired, dizziness, constipation, dry mouth, and restlessness. Other side effects include low blood pressure with standing, allergic reactions, neuroleptic malignant syndrome, diabetes mellitus, seizures, and tardive dyskinesia. In older people with dementia, its use increases the risk of death. Use in the later part of pregnancy may result in a movement disorder in the baby for some time after birth. Although its mechanism of action is not entirely clear, it is known to block dopamine and serotonin receptors.