HIF1AN
Sign in to saveAlso known as FIH1, hypoxia inducible factor 1 alpha subunit inhibitor, hypoxia inducible factor 1 subunit alpha inhibitor, HIFAN
Hypoxia-inducible factor 1-alpha inhibitor (FIH) is a protein that in humans is encoded by the HIF1AN gene.
In the Vinony graph
Vinony's link graph records 4 inbound references to HIF1AN, and connects out to PubMed, human chromosome 10 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 10.
Vinony links it to 5 Wikipedia language editions.
Gene data
HIF1AN- Name
- hypoxia inducible factor 1 subunit alpha inhibitor
- Type
- protein-coding
- Position
- 100,529,072–100,681,896 (+)
- Aliases
- FIH1
- Ensembl
- ENSG00000166135
- RefSeq RNA
- NM_017902.3, XM_011539940.3, XM_054366249.1
- RefSeq protein
- NP_060372.2, XP_011538242.1, XP_054222224.1
Enables several functions, including 2-oxoglutarate-dependent dioxygenase activity; NF-kappaB binding activity; and transition metal ion binding activity. Involved in several processes, including negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia; and protein hydroxylation. Located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. Colocalizes with nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
hypoxia inducible factor 1 subunit alpha inhibitor
- Symbol
- HIF1AN
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:100,529,072-100,681,896
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein HIF1AN PDB 1h2k.png
Show 8 more facts
- HomoloGene ID
- 9906
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/55662
- genomic end
- 102319755
- genomic start
- 102288829
- chromosome
- human chromosome 10
- cytogenetic location
- 10q24.31
- expressed in
- islet of Langerhans
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Hypoxia-inducible factor 1-alpha inhibitor (FIH) is a protein that in humans is encoded by the HIF1AN gene.
== Interactions ==
Excerpted from Wikipedia’s “HIF1AN” article, available under the CC BY-SA 4.0 licence.