HINT1

Also known as HINT, NMAN, PKCI-1, PRKCNH1, histidine triad nucleotide binding protein 1

Histidine triad nucleotide-binding protein 1 also known as '''adenosine 5'-monophosphoramidase' is an enzyme that in humans is encoded by the HINT1'' gene.

Gene data

HINT1

Name: histidine triad nucleotide binding protein 1
Type: protein-coding
Position: 131,155,383–131,224,468 (−)
Aliases: HINT, NMAN, PKCI-1, PRKCNH1
Ensembl: ENSG00000169567
RefSeq RNA: NM_001437949.1, NM_001437950.1, NM_005340.7, NR_024610.3, NR_024611.3
RefSeq protein: NP_001424878.1, NP_001424879.1, NP_005331.1

This gene encodes a protein that hydrolyzes purine nucleotide phosphoramidates substrates, including AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif. This gene is considered a tumor suppressor gene. In addition, mutations in this gene can cause autosomal recessive neuromyotonia and axonal neuropathy. There are several related pseudogenes on chromosome 7. Several transcript variants have been observed. [provided by RefSeq, Dec 2015].

Pathways

Developmental Biology MITF-M-regulated melanocyte development Regulation of MITF-M-dependent genes involved in apoptosis Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Transcriptional and post-translational regulation of MITF-M expression and activity MITF-M-dependent gene expression

via MyGene.info

Gene · Ensembl

histidine triad nucleotide binding protein 1

Symbol: HINT1
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:131,155,383-131,224,468
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein HINT1 PDB 1av5.png

Show 8 more facts

HomoloGene ID: 3904
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/3094
genomic end: 131224468
genomic start: 131155383
chromosome: human chromosome 5
cytogenetic location: 5q23.3
expressed in: spinal ganglia

Sources (5)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

See also
References
Further reading

Histidine triad nucleotide-binding protein 1 also known as '''adenosine 5'-monophosphoramidase' is an enzyme that in humans is encoded by the HINT1'' gene.

HINT1 hydrolyzes purine nucleotide phosphoramidates with a single phosphate group. In addition, functions as scaffolding protein that modulates transcriptional activation.

Excerpted from Wikipedia’s “HINT1” article, available under the CC BY-SA 4.0 licence.