HINT1

Also known as HINT, NMAN, PKCI-1, PRKCNH1, histidine triad nucleotide binding protein 1

Histidine triad nucleotide-binding protein 1 also known as '''adenosine 5'-monophosphoramidase' is an enzyme that in humans is encoded by the HINT1'' gene.

Gene data

HINT1

Name: histidine triad nucleotide binding protein 1
Type: protein-coding
Position: 131,155,383–131,224,468 (−)
Aliases: HINT, NMAN, PKCI-1, PRKCNH1
Ensembl: ENSG00000169567
RefSeq RNA: NM_001437949.1, NM_001437950.1, NM_005340.7, NR_024610.3, NR_024611.3
RefSeq protein: NP_001424878.1, NP_001424879.1, NP_005331.1

This gene encodes a protein that hydrolyzes purine nucleotide phosphoramidates substrates, including AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif. This gene is considered a tumor suppressor gene. In addition, mutations in this gene can cause autosomal recessive neuromyotonia and axonal neuropathy. There are several related pseudogenes on chromosome 7. Several transcript variants have been observed. [provided by RefSeq, Dec 2015].

Gene Ontology

Biological process

regulation of DNA-templated transcription

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Article

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See also
References
Further reading

Histidine triad nucleotide-binding protein 1 also known as '''adenosine 5'-monophosphoramidase' is an enzyme that in humans is encoded by the HINT1'' gene.

HINT1 hydrolyzes purine nucleotide phosphoramidates with a single phosphate group. In addition, functions as scaffolding protein that modulates transcriptional activation.