humanin
Sign in to saveAlso known as Humanin mitochondrial, HNM
thumb|The humanin gene is found within the 16S rRNA gene (MT-RNR2) in the mitochondrial genome Humanin is a micropeptide encoded in the mitochondrial genome by the 16S ribosomal RNA gene, MT-RNR2. Its structure contains a three-turn α-helix, and no symmetry.
Protein · UniProt
Humanin
- Gene
- MT-RNR2
- Organism
- Homo sapiens (Human)
- Length
- 24 aa
- Molecular mass
- 2,687 Da
- Evidence
- 1: Evidence at protein level
Plays a role as a neuroprotective factor (PubMed:11371646, PubMed:11717357, PubMed:12154011, PubMed:12787071, PubMed:12860203, PubMed:19386761). Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease (PubMed:11371646, PubMed:11717357, PubMed:12154011, PubMed:12787071, PubMed:12860203, PubMed:19386761). Mediates its neuroprotective effect by binding to the humanin receptor complex; binding of MT-RNR2 activates the intracellular JAK-STAT3 signaling pathways (PubMed:16005025, PubMed:19386761, PubMed:273…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
2 registered- COMPLETEDHumanin Isoforms in Cardiac Muscle and Blood Plasma and Major Complications After Cardiac OperationUniversity of Tartu · NCT03431844
- UNKNOWNClinical Value of Plasma Humanin in Acute Kidney InjuryGuangdong Provincial People's Hospital · NCT06105229
~6 min read
Article
9 sectionsContents
- Gene
- Protein
- Other species
- Function
- Interactions
- Discovery
- Research
- See also
- References
thumb|The humanin gene is found within the 16S rRNA gene (MT-RNR2) in the mitochondrial genome Humanin is a micropeptide encoded in the mitochondrial genome by the 16S ribosomal RNA gene, MT-RNR2. Its structure contains a three-turn α-helix, and no symmetry.
In in vitro and animal models, it appears to have cytoprotective effects.