Structure via PubChem · Public domain (PubChem)
hydroxycarbamide
Sign in to saveAlso known as Droxia®, Hydrea®, SQ-1089, Hydroxycarbamidum, Hidroxicarbamida, Hydroxyurea, N-Carbamoylhydroxylamine
Hydroxycarbamide, also known as hydroxyurea, is an antimetabolite medication used in sickle-cell disease, essential thrombocythemia, chronic myelogenous leukemia, polycythemia vera, and cervical cancer. In sickle-cells disease it increases fetal hemoglobin and decreases the number of attacks. It is taken by mouth.
Key facts
- Drug.N
- 2
- Drug.O
- 2
- Drug.SMILES
- O=C(N)NO
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 458281479
- Drug.image
- Hydroxyurea.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 140
- Drug.alt
- Structural formulas
- Drug.image2
- Hydroxyurea-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.USAN
- Hydroxyurea
- Drug.tradename
- Droxia, Hydrea, Siklos, others
- Drug.MedlinePlus
- a682004
- Drug.DailyMedID
- Hydroxyurea
- Drug.pregnancy_AU
- D
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- L01
via Wikipedia infobox
Chemical data
- Formula
- CH4N2O2
- Molecular weight
- 76.055 g/mol
- IUPAC name
- hydroxyurea
- SMILES
- C(=O)(N)NO
- InChIKey
- VSNHCAURESNICA-UHFFFAOYSA-N
- XLogP
- -1.8
- Polar surface area
- 75.4 Ų
- H-bond donors
- 3
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Research
14,633 papers- Ruxolitinib Versus Best Available Therapy for Polycythemia Vera Intolerant or Resistant to Hydroxycarbamide in a Randomized Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
- Hydroxyurea (hydroxycarbamide) for sickle cell disease.The Cochrane database of systematic reviews · 2022
- Hydroxyurea (hydroxycarbamide) for transfusion-dependent β-thalassaemia.The Cochrane database of systematic reviews · 2019
- Guidelines for the use of hydroxycarbamide in children and adults with sickle cell disease: A British Society for Haematology Guideline.British journal of haematology · 2018
- Hydroxycarbamide: clinical aspects.Comptes rendus biologies · 2013
via PubMed
Wikidata facts
- Mass
- 76.027
Show 4 more facts
- chemical formula
- CH₄N₂O₂
- World Health Organisation international non-proprietary name
- hydroxycarbamide
- canonical SMILES
- C(=O)(N)NO
- Commons category
- Hydroxyurea
Sources (8)
via Wikidata · CC0
~8 min read
Article
9 sectionsContents
- Medical uses
- Side effects
- Mechanism of action
- Natural occurrence
- Chemistry
- Pharmacology
- Society and culture
- Brand names
- References
Hydroxycarbamide, also known as hydroxyurea, is an antimetabolite medication used in sickle-cell disease, essential thrombocythemia, chronic myelogenous leukemia, polycythemia vera, and cervical cancer. In sickle-cells disease it increases fetal hemoglobin and decreases the number of attacks. It is taken by mouth.
Common side effects include bone marrow suppression, fevers, loss of appetite, psychiatric problems, shortness of breath, and headaches. There is also concern that it increases the risk of later cancer. Use during pregnancy is typically harmful to the fetus. Hydroxycarbamide is in the antineoplastic family of medications.<!-- It is on the World Health Organization's List of Essential Medicines. Hydroxycarbamide is available as a generic medication.