invadopodia
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thumbnail|right|A microscope picture of a cell's invadopodium. Invadopodia are actin-rich protrusions of the plasma membrane that are associated with degradation of the extracellular matrix in cancer invasiveness and metastasis. Very similar to podosomes, invadopodia are found in invasive cancer cells and are important for their ability to invade through the extracellular matrix, especially in cancer cell extravasation. Invadopodia are generally visualized by the holes they create in ECM (fibronectin, collagen etc.)-coated plates, in combination with immunohistochemistry for the invadopodia l
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Vinony's link graph records 18 inbound references to invadopodia, and connects out to plasma membrane, digital object identifier and PubMed.
It sits within the topics Cell anatomy and Membrane biology.
Vinony links it to 5 Wikipedia language editions.
~7 min read
Encyclopedic overview
6 sectionsContents
- History and controversy
- Structure and formation
- Role in cancer metastasis
- Therapeutic relevance
- See also
- References
thumbnail|right|A microscope picture of a cell's invadopodium. Invadopodia are actin-rich protrusions of the plasma membrane that are associated with degradation of the extracellular matrix in cancer invasiveness and metastasis. Very similar to podosomes, invadopodia are found in invasive cancer cells and are important for their ability to invade through the extracellular matrix, especially in cancer cell extravasation. Invadopodia are generally visualized by the holes they create in ECM (fibronectin, collagen etc.)-coated plates, in combination with immunohistochemistry for the invadopodia localizing proteins such as cortactin, actin, Tks5 etc. Invadopodia can also be used as a marker to quantify the invasiveness of cancer cell lines in vitro using a hyaluronic acid hydrogel assay.
==History and controversy==
Excerpted from Wikipedia’s “invadopodia” article, available under the CC BY-SA 4.0 licence.