IPO7

Name

importin 7

Type

protein-coding

Position

9,384,604–9,448,127 (+)

Aliases

Imp7, RANBP7

Ensembl

ENSG00000205339

RefSeq RNA

NM_006391.3

RefSeq protein

NP_006382.1

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

importin 7

Symbol

IPO7

Biotype

Protein coding

Organism

Homo sapiens

Location

11:9,384,604-9,448,127

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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