IQSEC1
Sign in to saveAlso known as ARF-GEP100, ARFGEP100, BRAG2, GEP100, IQ motif and Sec7 domain 1, IQ motif and Sec7 domain ArfGEF 1, IDDSSBA
IQ motif and SEC7 domain-containing protein 1 also known as ARF-GEP100 (ADP-Ribosylation Factor - Guanine nucleotide-Exchange Protein - 100-kDa) is a protein that in humans is encoded by the IQSEC1 gene.
Gene data
IQSEC1- Name
- IQ motif and Sec7 domain ArfGEF 1
- Type
- protein-coding
- Position
- 12,897,043–13,283,281 (−)
- Aliases
- ARF-GEP100, ARFGEP100, BRAG2, GEP100, IDDSSBA
- Ensembl
- ENSG00000144711
- RefSeq RNA
- NM_001134382.3, NM_001330619.3, NM_001376938.2, NM_014869.8, XM_011534306.4
- RefSeq protein
- NP_001127854.1, NP_001317548.1, NP_001363867.1, NP_055684.3, XP_011532608.1
Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including positive regulation of focal adhesion disassembly; positive regulation of keratinocyte migration; and regulation of postsynaptic neurotransmitter receptor internalization. Located in nucleolus. Implicated in intellectual developmental disorder with short stature and behavioral abnormalities. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
IQ motif and Sec7 domain ArfGEF 1
- Symbol
- IQSEC1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:12,897,043-13,283,281
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 82429
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9922
- genomic end
- 13283281
- genomic start
- 12897043
- chromosome
- human chromosome 3
- cytogenetic location
- 3p25.2-p25.1
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- References
- Further reading
- External links
IQ motif and SEC7 domain-containing protein 1 also known as ARF-GEP100 (ADP-Ribosylation Factor - Guanine nucleotide-Exchange Protein - 100-kDa) is a protein that in humans is encoded by the IQSEC1 gene.
==Function== The ARF-GEP100 protein is involved in signal transduction. It is a guanine nucleotide exchange factor that promotes binding of GTP to ADP ribosylation factor protein ARF6 and to a lesser extent ARF1 and ARF5. This activates the ADP-ribosylation activity of the target protein and cause it to modify its substrates. ARF-GEP100, through activation of ARF6, is therefore involved in the control of processes such as endocytosis of plasma membrane proteins, E-cadherin recycling and actin cytoskeleton remodeling. ARF-GEP100 appears particularly important in regulating cell adhesion, with reductions in the level of this protein causing enhanced spreading and attachment of cells.
Excerpted from Wikipedia’s “IQSEC1” article, available under the CC BY-SA 4.0 licence.