IZUMO1
Sign in to saveAlso known as IZUMO, OBF, izumo sperm-egg fusion 1
Izumo sperm-egg fusion protein 1 (Sperm-specific protein izumo) is encoded in humans by the IZUMO1 gene. In mammalian fertilisation, IZUMO1 binds to its egg receptor counterpart, Juno, to facilitate recognition and fusion of the gametes.
Gene data
IZUMO1- Name
- izumo sperm-oocyte fusion 1
- Type
- protein-coding
- Position
- 48,740,852–48,746,909 (−)
- Aliases
- IZUMO, OBF
- Ensembl
- ENSG00000182264
- RefSeq RNA
- NM_001321864.1, NM_001321865.1, NM_182575.3, NR_135832.1
- RefSeq protein
- NP_001308793.1, NP_001308794.1, NP_872381.2
The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
izumo sperm-oocyte fusion 1
- Symbol
- IZUMO1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:48,740,852-48,746,909
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- name in kana
- いずも
- HomoloGene ID
- 77701
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/284359
- genomic end
- 49250166
- genomic start
- 49244109
- chromosome
- human chromosome 19
- cytogenetic location
- 19q13.33
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Function
- References
- Further reading
Izumo sperm-egg fusion protein 1 (Sperm-specific protein izumo) is encoded in humans by the IZUMO1 gene. In mammalian fertilisation, IZUMO1 binds to its egg receptor counterpart, Juno, to facilitate recognition and fusion of the gametes.
==Function==
Excerpted from Wikipedia’s “IZUMO1” article, available under the CC BY-SA 4.0 licence.