Structure via PubChem · Public domain (PubChem)
JZL195
Sign in to saveJZL195 is a potent inhibitor of both fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), the primary enzymes responsible for degrading the endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively.
Chemical data
- Formula
- C24H23N3O5
- Molecular weight
- 433.5 g/mol
- IUPAC name
- (4-nitrophenyl) 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate
- SMILES
- C1CN(CCN1CC2=CC(=CC=C2)OC3=CC=CC=C3)C(=O)OC4=CC=C(C=C4)[N+](=O)[O-]
- InChIKey
- QNYRAEKLMNDRFY-UHFFFAOYSA-N
- XLogP
- 4.3
- Polar surface area
- 87.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 433.16377083599997
Show 3 more facts
- canonical SMILES
- c1ccc(cc1)Oc2cccc(c2)CN3CCN(CC3)C(=O)Oc4ccc(cc4)[N+](=O)[O-]
- chemical formula
- C₂₄H₂₃N₃O₅
- Commons category
- JZL195
Sources (1)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
JZL195 is a potent inhibitor of both fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), the primary enzymes responsible for degrading the endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively.
== See also == JZL184 JNJ-42165279
Excerpted from Wikipedia’s “JZL195” article, available under the CC BY-SA 4.0 licence.