Structure via PubChem · Public domain (PubChem)
JWH-167
Sign in to saveJWH-167 (1-pentyl-3-(phenylacetyl)indole) is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about 1.75 times selectivity for CB1 with a Ki of 90 nM ± 17 and 159 nM ± 14 at CB2. Similar to the related 2'-methoxy compound JWH-250, and the 2'-chloro compound JWH-203, JWH-167 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds.
Chemical data
- Formula
- C21H23NO
- Molecular weight
- 305.4 g/mol
- IUPAC name
- 1-(1-pentylindol-3-yl)-2-phenylethanone
- SMILES
- CCCCCN1C=C(C2=CC=CC=C21)C(=O)CC3=CC=CC=C3
- InChIKey
- AMCPOEOUXQWESI-UHFFFAOYSA-N
- XLogP
- 5
- Polar surface area
- 22 Ų
- H-bond donors
- 0
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 305.178
Show 2 more facts
- chemical formula
- C₂₁H₂₃NO
- canonical SMILES
- CCCCCN1C=C(C2=CC=CC=C21)C(=O)CC3=CC=CC=C3
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
JWH-167 (1-pentyl-3-(phenylacetyl)indole) is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about 1.75 times selectivity for CB1 with a Ki of 90 nM ± 17 and 159 nM ± 14 at CB2. Similar to the related 2'-methoxy compound JWH-250, and the 2'-chloro compound JWH-203, JWH-167 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds.
In the United States, CB1 receptor agonists of the 3-phenylacetylindole class such as JWH-167 are Schedule I Controlled Substances.
Excerpted from Wikipedia’s “JWH-167” article, available under the CC BY-SA 4.0 licence.