Structure via PubChem · Public domain (PubChem)
JWH-198
Sign in to saveJWH-198 is a drug from the aminoalkylindole and naphthoylindole families which acts as a cannabinoid receptor agonist. It was invented by the pharmaceutical company Sanofi-Winthrop in the early 1990s. JWH-198 has a binding affinity at the CB1 receptor of 10 nM, binding around four times more tightly than the parent compound JWH-200, which has no substitution on the naphthoyl ring. It has been used mainly in molecular modelling of the cannabinoid receptors.
In the Vinony graph
Vinony's link graph records 449 inbound references to JWH-198, and connects out to JWH-210, synhexyl and digital object identifier.
It is catalogued under topics including 4-Morpholinyl compounds, Aminoalkylindoles and CB1 receptor agonists.
Vinony links it to 4 Wikipedia language editions.
Chemical data
- Formula
- C26H26N2O3
- Molecular weight
- 414.5 g/mol
- IUPAC name
- (4-methoxynaphthalen-1-yl)-[1-(2-morpholin-4-ylethyl)indol-3-yl]methanone
- SMILES
- COC1=CC=C(C2=CC=CC=C21)C(=O)C3=CN(C4=CC=CC=C43)CCN5CCOCC5
- InChIKey
- QWHSUXWDDKWTOG-UHFFFAOYSA-N
- XLogP
- 4.2
- Polar surface area
- 43.7 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 414.194
Show 2 more facts
- chemical formula
- C₂₆H₂₆N₂O₃
- canonical SMILES
- COC1=CC=C(C2=CC=CC=C21)C(=O)C3=CN(C4=CC=CC=C43)CCN5CCOCC5
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
JWH-198 is a drug from the aminoalkylindole and naphthoylindole families which acts as a cannabinoid receptor agonist. It was invented by the pharmaceutical company Sanofi-Winthrop in the early 1990s. JWH-198 has a binding affinity at the CB1 receptor of 10 nM, binding around four times more tightly than the parent compound JWH-200, which has no substitution on the naphthoyl ring. It has been used mainly in molecular modelling of the cannabinoid receptors.
In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-198 are Schedule I Controlled Substances.
Excerpted from Wikipedia’s “JWH-198” article, available under the CC BY-SA 4.0 licence.