KDSR

Also known as 6330410P18Rik, 9430079B08Rik, Fvt1, DHSR, SDR35C1, 3-ketodihydrosphingosine reductase, 3-dehydrosphinganine reductase

protein-coding gene in the species Homo sapiens

In the Vinony graph

Within Vinony's link graph, KDSR is referenced by 4 other articles, and connects out to Q180686, Q229883 and nicotinamide adenine dinucleotide phosphate.

It sits within the topics EC 1.1.1, Enzymes of unknown structure and Genes on human chromosome 18.

Its subject is documented across 9 Wikipedia language editions.

Gene data

KDSR

Name: 3-ketodihydrosphingosine reductase
Type: protein-coding
Position: 63,327,566–63,367,615 (−)
Aliases: DHSR, EKVP4, FVT1, SDR35C1
Ensembl: ENSG00000119537
RefSeq RNA: NM_002035.4
RefSeq protein: NP_002026.1

The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy. [provided by RefSeq, Jul 2008].