KLRG1

Also known as 2F1, CLEC15A, MAFA, MAFA-2F1, MAFA-L, MAFA-LIKE, killer cell lectin like receptor G1

Killer cell lectin-like receptor subfamily G member 1 is a protein that in humans is encoded by the KLRG1 gene.

Gene data

KLRG1

Name: killer cell lectin like receptor G1
Type: protein-coding
Position: 8,950,044–9,010,760 (+)
Aliases: 2F1, CLEC15A, MAFA, MAFA-2F1, MAFA-L, MAFA-LIKE
Ensembl: ENSG00000139187
RefSeq RNA: NM_001329099.2, NM_001329101.2, NM_001329102.2, NM_001329103.2, NM_005810.4
RefSeq protein: NP_001316028.1, NP_001316030.1, NP_001316031.1, NP_001316032.1, NP_005801.3

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. [provided by RefSeq, Jun 2016].