TOX

Also known as TOX1, thymocyte selection associated high mobility group box

thumb|TOX pathway Thymocyte selection-associated high mobility group box protein TOX is a protein that in humans is encoded by the TOX gene. TOX drives T-cell exhaustion and plays a role in innate lymphoid cell development.

Gene data

TOX

Name: thymocyte selection associated high mobility group box
Type: protein-coding
Position: 58,805,412–59,119,279 (−)
Aliases: TOX1
Ensembl: ENSG00000198846
RefSeq RNA: NM_014729.3
RefSeq protein: NP_055544.1

The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.[provided by RefSeq, Apr 2009].

Gene Ontology

Biological process

natural killer cell differentiation CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment

Article

11 sections

Contents

Structure
TOX subfamily
Function
T cell exhaustion
Effector function
Cancer & chronic infection
Activation
T-cell development
Innate lymphoid cells development
References
Further reading

== Structure == The TOX gene encodes a protein that belongs to a large superfamily of chromatin associated proteins that share an approximately 75 amino acid DNA binding motif, the HMG (high mobility group)-box (named after that found in the canonical member of the family, high mobility group protein 1). Some high mobility group (HMG) box proteins (e.g., LEF1) contain a single HMG box motif and bind DNA in a sequence-specific manner, while other members of this family (e.g., HMGB1) have multiple HMG boxes and bind DNA in a sequence-independent but structure-dependent manner. While TOX has a single HMG-box motif, it is predicted to bind DNA in a sequence-independent manner.