Also known as TOX1, thymocyte selection associated high mobility group box
thumb|TOX pathway Thymocyte selection-associated high mobility group box protein TOX is a protein that in humans is encoded by the TOX gene. TOX drives T-cell exhaustion and plays a role in innate lymphoid cell development.
Gene data
TOX- Name
- thymocyte selection associated high mobility group box
- Type
- protein-coding
- Position
- 58,805,412–59,119,279 (−)
- Aliases
- TOX1
- Ensembl
- ENSG00000198846
- RefSeq RNA
- NM_014729.3
- RefSeq protein
- NP_055544.1
The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.[provided by RefSeq, Apr 2009].
Gene Ontology
Biological process
via MyGene.info
Gene · Ensembl
thymocyte selection associated high mobility group box
- Symbol
- TOX
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:58,805,412-59,119,310
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein TOX PDB 2co9.png
Show 5 more facts
- HomoloGene ID
- 8822
- exact match
- identifiers.org/ncbigene/9760
- genomic end
- 59119147
- genomic start
- 58805412
- cytogenetic location
- 8q12.1
Sources (3)
via Wikidata · CC0
~5 min read
Article
11 sectionsContents
- Structure
- TOX subfamily
- Function
- T cell exhaustion
- Effector function
- Cancer & chronic infection
- Activation
- T-cell development
- Innate lymphoid cells development
- References
- Further reading
thumb|TOX pathway Thymocyte selection-associated high mobility group box protein TOX is a protein that in humans is encoded by the TOX gene. TOX drives T-cell exhaustion and plays a role in innate lymphoid cell development.
== Structure == The TOX gene encodes a protein that belongs to a large superfamily of chromatin associated proteins that share an approximately 75 amino acid DNA binding motif, the HMG (high mobility group)-box (named after that found in the canonical member of the family, high mobility group protein 1). Some high mobility group (HMG) box proteins (e.g., LEF1) contain a single HMG box motif and bind DNA in a sequence-specific manner, while other members of this family (e.g., HMGB1) have multiple HMG boxes and bind DNA in a sequence-independent but structure-dependent manner. While TOX has a single HMG-box motif, it is predicted to bind DNA in a sequence-independent manner.