ASXL3

Also known as BRPS, KIAA1713, additional sex combs like 3, transcriptional regulator, ASXL transcriptional regulator 3

Putative Polycomb group protein ASXL3 is a protein that in humans is encoded by the ASXL3 gene.

In the Vinony graph

Vinony's link graph records 8 inbound references to ASXL3, and connects out to PubMed, human chromosome 18 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 18.

Vinony links it to 6 Wikipedia language editions.

Gene data

ASXL3

Name: ASXL transcriptional regulator 3
Type: protein-coding
Position: 33,578,219–33,751,195 (+)
Aliases: BRPS, KIAA1713
Ensembl: ENSG00000141431
RefSeq RNA: NM_030632.3, XM_005258356.2, XM_011526205.3, XM_011526206.3, XM_011526209.2
RefSeq protein: NP_085135.1, XP_005258413.1, XP_011524507.1, XP_011524508.1, XP_011524511.1

This gene encodes a protein containing a plant homeodomain (PHD) zinc finger domain that plays a role in the regulation of gene transcription. The encoded protein has been shown to negatively regulate lipogenesis by binding to and inhibiting the transcriptional activity of two nuclear hormone receptors, oxysterols receptor LXR-alpha (LXRalpha) and thyroid hormone receptor beta (TRbeta). The encoded protein may also inhibit histone deubiquitination. Mutations in this gene have been identified in human patients with Bainbridge-Ropers syndrome, which is characterized by feeding difficulties, developmental delay and other features. [provided by RefSeq, May 2017].