Structure via PubChem · Public domain (PubChem)
letrozole
Sign in to saveAlso known as FEM345, Femara®, Letrozol
Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor medication that is used in the treatment of breast cancer for post-menopausal women.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 460779010
- Drug.image
- Letrozole.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 225
- Drug.image2
- Letrozol3D.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 225
- Drug.tradename
- Femara, others
- Drug.MedlinePlus
- a698004
- Drug.DailyMedID
- Letrozole
- Drug.routes_of_administration
- By mouth
- Drug.class
- Aromatase inhibitor; Antiestrogen
- Drug.ATC_prefix
- L02
- Drug.ATC_suffix
- BG04
- Drug.legal_CA
- Schedule VII
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C17H11N5
- Molecular weight
- 285.3 g/mol
- IUPAC name
- 4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile
- SMILES
- C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3
- InChIKey
- HPJKCIUCZWXJDR-UHFFFAOYSA-N
- XLogP
- 2.7
- Polar surface area
- 78.3 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
5,301 papers- Palbociclib and Letrozole in Advanced Breast Cancer.The New England journal of medicine · 2016
- Letrozole for Female Infertility.Frontiers in endocrinology · 2021
- Letrozole: Pharmacology, toxicity and potential therapeutic effects.Life sciences · 2022
- Letrozole.Expert opinion on drug metabolism & toxicology · 2010
- Palbociclib plus letrozole as first-line therapy in estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer with extended follow-up.Breast cancer research and treatment · 2019
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 285.101445
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₇H₁₁N₅
- canonical SMILES
- C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3
- World Health Organisation international non-proprietary name
- letrozole
- defined daily dose
- 2.5
- subject has role
- antineoplastic
- physically interacts with
- cytochrome P450 family 19 subfamily A member 1
- Commons category
- Letrozole
Sources (9)
via Wikidata · CC0
~6 min read
Encyclopedic overview
13 sectionsContents
- Medical uses
- Breast cancer
- Comparison with tamoxifen
- Ovulation induction
- Medical Abortion
- Use in sports
- Contraindications
- Side effects
- Interactions
- Pharmacology
- Pharmacodynamics
- Research
- References
Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor medication that is used in the treatment of breast cancer for post-menopausal women.
It was patented in 1986 and approved for medical use in 1996. In 2021, it was the 222nd most commonly prescribed medication in the United States, with more than 1million prescriptions. It is on the World Health Organization's List of Essential Medicines.
Excerpted from Wikipedia’s “letrozole” article, available under the CC BY-SA 4.0 licence.