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GeneQ18028555· pop 6· linked from 17 articles

LIG1

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Also known as DNA ligase 1, LIGI, hLig1, IMD96

protein-coding gene in the species Homo sapiens

Gene data

LIG1

Name: DNA ligase 1
Type: protein-coding
Position: 48,115,445–48,170,654 (−)
Aliases: IMD96, LIGI, hLig1
Ensembl: ENSG00000105486
RefSeq RNA: NM_000234.3, NM_001289063.2, NM_001289064.2, NM_001320970.2, NM_001320971.2
RefSeq protein: NP_000225.1, NP_001275992.1, NP_001275993.1, NP_001307899.1, NP_001307900.1

This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].

Gene Ontology

Biological process

lagging strand elongation DNA repair DNA repair base-excision repair base-excision repair, gap-filling mismatch repair DNA recombination anatomical structure morphogenesis

Molecular function

DNA binding DNA binding DNA ligase activity DNA ligase activity DNA ligase activity DNA ligase activity DNA ligase (ATP) activity DNA ligase (ATP) activity

Cellular component

nucleus nucleus nucleus nucleoplasm nucleoplasm

Pathways

DNA replication - Homo sapiens (human)Base excision repair - Homo sapiens (human)Nucleotide excision repair - Homo sapiens (human)Mismatch repair - Homo sapiens (human)POLB-Dependent Long Patch Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway Developmental Biology Telomere Maintenance HIV Life Cycle Early Phase of HIV Life Cycle

via MyGene.info

Gene · Ensembl

DNA ligase 1

Symbol: LIG1
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:48,115,444-48,170,654
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein LIG1 PDB 1x9n.png

Show 5 more facts

HomoloGene ID: 197
exact match: identifiers.org/ncbigene/3978
genomic end: 48673860
genomic start: 48618702
cytogenetic location: 19q13.33

Sources (4)

via Wikidata · CC0

Available in 6 languages

via Wikidata sitelinks · CC0

Categories

EC 6.5.1 Genes on human chromosome 19