ligases
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In biochemistry, a ligase is an enzyme that can catalyze the joining (ligation) of two molecules by forming a new chemical bond. This is typically via hydrolysis of a small pendant chemical group on one of the molecules, typically resulting in the formation of new C-O, C-S, or C-N bonds. For example, DNA ligase can join two complementary fragments of nucleic acid by forming phosphodiester bonds, and repair single stranded breaks that arise in double stranded DNA during replication.
Research
134,274 papers- RNA ligases.Current protocols in molecular biology · 2001
- Exploring the biological and chemical complexity of the ligases.Journal of molecular biology · 2014
- Self-regulating ubiquitin ligases.The EMBO journal · 2017
- [Novel L-amino acid ligases catalyzing oligopeptide synthesis].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan · 2010
- Development of a general bioluminescent activity assay for peptide ligases.The FEBS journal · 2022
via PubMed
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Article
6 sectionsContents
- Nomenclature
- Classification
- Membrane-associated ligases
- Etymology and pronunciation
- See also
- References
In biochemistry, a ligase is an enzyme that can catalyze the joining (ligation) of two molecules by forming a new chemical bond. This is typically via hydrolysis of a small pendant chemical group on one of the molecules, typically resulting in the formation of new C-O, C-S, or C-N bonds. For example, DNA ligase can join two complementary fragments of nucleic acid by forming phosphodiester bonds, and repair single stranded breaks that arise in double stranded DNA during replication.
In general, a ligase catalyzes the following dehydration reaction, thus joining molecules A and B: