LRTOMT
Sign in to saveAlso known as CFAP111, DFNB63, LRRC51, leucine rich transmembrane and O-methyltransferase domain containing, TOMT, LRRC51-TOMT
Leucine rich transmembrane and O-methyltransferase domain containing is a protein that is encoded by the LRTOMT gene in humans. This locus represents naturally occurring read-through transcript between the neighboring LRRC51 (leucine-rich repeat containing 51) and TOMT (transmembrane O-methyltransferase) genes on chromosome 11. Mutations in LRTOMT are associated with the DFNB63 form of autosomal recessive nonsyndromic hearing loss.
Gene data
LRTOMT- Name
- leucine rich transmembrane and O-methyltransferase domain containing
- Type
- protein-coding
- Aliases
- CFAP111, DFNB63, LRRC51, LRRC51-TOMT
This locus represents naturally occurring readthrough transcription between the neighboring LRRC51 (leucine-rich repeat containing 51) and TOMT (transmembrane O-methyltransferase) genes on chromosome 11. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. Multiple reports implicate mutations in this gene in nonsyndromic deafness.[provided by RefSeq, Feb 2021].
via MyGene.info
Gene · Ensembl
leucine rich transmembrane and O-methyltransferase domain containing
- Symbol
- LRTOMT
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:72,080,331-72,110,782
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 19664
- exact match
- identifiers.org/ncbigene/220074
- cytogenetic location
- 11q13.4
- genomic start
- 71791382
- genomic end
- 71821828
Sources (6)
via Wikidata · CC0
~3 min read
Article
5 sectionsContents
- Gene
- Function
- Clinical significance
- References
- Further reading
Leucine rich transmembrane and O-methyltransferase domain containing is a protein that is encoded by the LRTOMT gene in humans. This locus represents naturally occurring read-through transcript between the neighboring LRRC51 (leucine-rich repeat containing 51) and TOMT (transmembrane O-methyltransferase) genes on chromosome 11. Mutations in LRTOMT are associated with the DFNB63 form of autosomal recessive nonsyndromic hearing loss.
== Gene ==