medroxyprogesterone

Also known as 17α-hydroxy-6α-methylprogesterone

Medroxyprogesterone (MP), is a progestin which is not used medically. A derivative, medroxyprogesterone acetate (MPA), is used as a medication in humans, and is far more widely known in comparison. Medroxyprogesterone is sometimes used as a synonym for medroxyprogesterone acetate, and what is almost always being referred to when the term is used is MPA and not medroxyprogesterone.

Research

10,012 papers

Endometriosis.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN · 1985
Depot-medroxyprogesterone acetate (DMPA) and cancer: memorandum from a WHO meeting.Bulletin of the World Health Organization · 1986
The effect of depot-medroxyprogesterone acetate on the fetus and nursing infant: a review.Contraception · 1981
Premenstrual syndrome.The Journal of clinical endocrinology and metabolism · 1991
Medroxyprogesterone acetate and homozygous sickle-cell disease.Lancet (London, England) · 1982

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Wikidata facts

Mass: 344.235145

Show 7 more facts

canonical SMILES: CC1CC2C(CCC3(C2CCC3(C(=O)C)O)C)C4(C1=CC(=O)CC4)C
chemical formula: C₂₂H₃₂O₃
isomeric SMILES: C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]4(C)CCC(=O)C=C14
NCI Thesaurus ID: C629
Commons category: Medroxyprogesterone
stylized name: medroxyPROGESTERone
defined daily dose: 7

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Article

6 sections

Contents

Pharmacology
Pharmacodynamics
Chemistry
Society and culture
Generic names
References

==Pharmacology== ===Pharmacodynamics=== Compared to MPA, medroxyprogesterone is over two orders of magnitude less potent as a progestogen. Medroxyprogesterone is also notable in that it is a minor metabolite of MPA. In addition to its progestagenic activity, medroxyprogesterone is a weak antiandrogen in vitro on human androgen receptor.