Structure via PubChem · Public domain (PubChem)
methoxyflurane
Sign in to saveAlso known as Penthrane®, Methyl 1,1-difluoro-2,2-dichloroethyl ether, Methoxyfluran, Methoflurane, Methoxyfluoran, Metoxiflurano, Methoxyfluranum
Methoxyflurane, sold under the brand name Penthrox (the "green whistle") among others, is an inhaled medication primarily used to reduce pain following an injury. It may also be used to reduce pain associated with minor medical procedures. Onset of pain relief is rapid and a standard dose typically lasts for up to 30 minutes. Use is only recommended with direct medical supervision.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 457473565
- Drug.image
- Methoxyflurane.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Methoxyflurane-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Penthrox, others
- Drug.pregnancy_AU
- C
- Drug.routes_of_administration
- Inhalation
- Drug.class
- Volatile anesthetic
- Drug.ATC_prefix
- N02
- Drug.ATC_suffix
- BG09
- Drug.legal_AU
- S4
- Drug.legal_BR
- C1
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
- Drug.legal_EU
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C3H4Cl2F2O
- Molecular weight
- 164.96 g/mol
- IUPAC name
- 2,2-dichloro-1,1-difluoro-1-methoxyethane
- SMILES
- COC(C(Cl)Cl)(F)F
- InChIKey
- RFKMCNOHBTXSMU-UHFFFAOYSA-N
- XLogP
- 2.2
- Polar surface area
- 9.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Wikidata facts
- Mass
- 163.960727
Show 11 more facts
- chemical formula
- C₃H₄Cl₂F₂O
- boiling point
- 220
- Commons category
- Methoxyflurane
- vapor pressure
- 23
- lower flammable limit
- 7
- NIOSH Pocket Guide ID
- 0389
- density
- 1.42
- melting point
- -36
- ceiling exposure limit
- 13.5
- canonical SMILES
- COC(C(Cl)Cl)(F)F
- World Health Organisation international non-proprietary name
- methoxyflurane
via Wikidata · CC0
~19 min read
Article
16 sectionsContents
- Medical use
- Side effects
- Kidney
- Liver
- Mechanism
- Pharmacokinetics
- Pharmacodynamics
- Heart
- Lungs
- Pain
- Central nervous system
- Chemical properties
- History
- Legal status
- References
- External links
Methoxyflurane, sold under the brand name Penthrox (the "green whistle") among others, is an inhaled medication primarily used to reduce pain following an injury. It may also be used to reduce pain associated with minor medical procedures. Onset of pain relief is rapid and a standard dose typically lasts for up to 30 minutes. Use is only recommended with direct medical supervision.
Common side effects include anxiety, headache, sleepiness, cough, and nausea. Serious side effects may include kidney problems, liver problems, low blood pressure, and severe anaesthetic reactions such as malignant hyperthermia. It may be used during pregnancy or breastfeeding, however there may be additional harmful side effects. It is only recommended in those who have a normal level of consciousness and stable blood pressure and heart rate. It is classified as a volatile anaesthetic.