methylation
Sign in to saveAlso known as GO:0032259
Methylation, in the chemical sciences, is the addition of a methyl group on a substrate, or the substitution of an atom (or group) by a methyl group. Methylation is a form of alkylation, with a methyl group replacing a hydrogen atom. These terms are commonly used in chemistry, biochemistry, soil science, and biology.
Research
563,660 papers- Lysine methylation: Implications in neurodegenerative disease.Brain research · 2019
- Enzymatic methylation of the amide bond.Current opinion in structural biology · 2020
- Discovering DNA Methylation, the History and Future of the Writing on DNA.Journal of the history of biology · 2022
- DNA methylation as a molecular biomarker in gastric cancer.Epigenomics · 2015
- Microbial Mercury Methylation in Aquatic Environments: A Critical Review of Published Field and Laboratory Studies.Environmental science & technology · 2019
via PubMed
Wikidata facts
Show 2 more facts
- Commons category
- Methylation
- exact match
- biomodels.net/SBO/SBO_0000214
via Wikidata · CC0
~11 min read
Article
21 sectionsContents
- In biology
- Methanogenesis
- ''O''-methyltransferases
- Proteins
- Methionine synthase
- Heavy metals: arsenic, mercury, cadmium
- Epigenetic methylation
- DNA methylation
- RNA methylation
- Protein methylation
- Evolution
- In chemistry
- Electrophilic methylation
- Eschweiler–Clarke methylation
- Diazomethane and trimethylsilyldiazomethane
- Nucleophilic methylation
- See also
- Biology topics
- Organic chemistry topics
- References
- External links
Methylation, in the chemical sciences, is the addition of a methyl group on a substrate, or the substitution of an atom (or group) by a methyl group. Methylation is a form of alkylation, with a methyl group replacing a hydrogen atom. These terms are commonly used in chemistry, biochemistry, soil science, and biology.
In biological systems, methylation is catalyzed by enzymes; such methylation can be involved in modification of heavy metals, regulation of gene expression, regulation of protein function, and RNA processing. In vitro methylation of tissue samples is also a way to reduce some histological staining artifacts. The reverse of methylation is demethylation.