opicapone

Also known as BIA 9-1067, compound 37d [PMID: 20334432]

Opicapone, sold under the brand name Ongentys, is a medication which is administered together with levodopa in people with Parkinson's disease. Opicapone is a catechol-O-methyltransferase (COMT) inhibitor.

Key facts

Drug.UNII: Y5929UIJ5N
Drug.image: Opicapone.svg
Drug.image_class: skin-invert-image
Drug.tradename: Ongentys, Ontilyv
Drug.DailyMedID: Opicapone
Drug.pregnancy_AU: B2
Drug.pregnancy_category: Not recommended
Drug.routes_of_administration: By mouth
Drug.ATC_prefix: N04
Drug.ATC_suffix: BX04
Drug.legal_AU: S4
Drug.legal_UK: POM
Drug.legal_US: Rx-only
Drug.legal_EU: Rx-only
Drug.legal_status: Rx-only
Drug.bioavailability: ~20%
Drug.protein_bound: 99.9%
Drug.metabolism: Mainly sulfation, also reduction, glucuronidation, methylation

via Wikipedia infobox

Wikidata facts

Mass: 411.997739

Show 4 more facts

canonical SMILES: Cc1c(Cl)c(C)[n+]([O-])c(Cl)c1-c1noc(-c2cc(O)c(O)c([N+](=O)[O-])c2)n1
chemical formula: C₁₅H₁₀Cl₂N₄O₆
Commons category: Opicapone
defined daily dose: 50

Sources (4)

via Wikidata · CC0

~9 min read

Article

13 sections

Contents

Medical uses
Contraindications
Side effects
Overdose
Interactions
Pharmacology
Mechanism of action
Pharmacokinetics
History
Society and culture
Legal status
References
Further reading

The most common side effects are dyskinesia (difficulty controlling movement), constipation, increased blood creatine kinase, hypotension/syncope, and decreased weight.