Structure via PubChem · Public domain (PubChem)
chlorphenoxamine
Sign in to saveChlorphenoxamine (Phenoxene) is an antihistamine and anticholinergic used as an antipruritic and antiparkinsonian agent. It is an analog of diphenhydramine.
Chemical data
- Formula
- C18H22ClNO
- Molecular weight
- 303.8 g/mol
- IUPAC name
- 2-[1-(4-chlorophenyl)-1-phenylethoxy]-N,N-dimethylethanamine
- SMILES
- CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCN(C)C
- InChIKey
- KKHPNPMTPORSQE-UHFFFAOYSA-N
- XLogP
- 4.1
- Polar surface area
- 12.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- Pruritus, allergic disease
via ChEMBL · EBI
Research
37 papers- Novel RP-HPLC-DAD approach for simultaneous determination of chlorphenoxamine hydrochloride and caffeine with their related substances.BMC chemistry · 2024
- Urinary metabolism of chlorphenoxamine in man.Arzneimittel-Forschung · 1987
- Chlorphenoxamine hydrochloride in parkinsonism. A controlled trial.British medical journal · 1961
- Smart green spectrophotometric estimation and content uniformity testing of chlorphenoxamine HCl and caffeine in bulk forms and combined pharmaceutical formulation.Scientific reports · 2025
- [Isolation of chlorphenoxamine metabolites in human urine and their identification].Arzneimittel-Forschung · 1987
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 303.139
- Has use
- medication
Show 4 more facts
- chemical formula
- C₁₈H₂₂ClNO
- subject has role
- muscarinic antagonist
- defined daily dose
- 80
- canonical SMILES
- CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCN(C)C
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
{{Drugbox |Verifiedfields = changed |Watchedfields = changed |verifiedrevid = 447811372 |IUPAC_name = {2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl}dimethylamine |image = Chlorphenoxamine.svg |image_class = skin-invert-image |Drugs.com = |routes_of_administration = Oral, topical |bioavailability = Well absorbed |metabolism = Likely liver |excretion = kidney |CAS_number_Ref = |CAS_number = 77-38-3 |CAS_supplemental = |ATC_prefix = D04 |ATC_suffix = AA34 |ATC_supplemental = |PubChem = 6475 |DrugBank_Ref = |DrugBank = DB09007 |ChemSpiderID_Ref = |ChemSpiderID = 6230 |ChEMBL_Ref = |ChEMBL = 2110774 |UNII_Ref = |UNII = 3UVD77BP8R |KEGG_Ref = |KEGG = D07198 |C=18 | H=22 | Cl=1 | N=1 | O=1 |smiles = Clc1ccc(cc1)C(OCCN(C)C)(c2ccccc2)C |StdInChI_Ref = |StdInChI = 1S/C18H22ClNO/c1-18(21-14-13-20(2)3,15-7-5-4-6-8-15)16-9-11-17(19)12-10-16/h4-12H,13-14H2,1-3H3 |StdInChIKey_Ref = |StdInChIKey = KKHPNPMTPORSQE-UHFFFAOYSA-N }}
Chlorphenoxamine (Phenoxene) is an antihistamine and anticholinergic used as an antipruritic and antiparkinsonian agent. It is an analog of diphenhydramine.
Excerpted from Wikipedia’s “chlorphenoxamine” article, available under the CC BY-SA 4.0 licence.
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