Structure via PubChem · Public domain (PubChem)
misonidazole
Sign in to saveMisonidazole is a radiosensitizer that was investigated in clinical trials. It was used in these trials for radiation therapy to cause normally resistant hypoxic tumor cells to become sensitive to the treatment.
Chemical data
- Formula
- C7H11N3O4
- Molecular weight
- 201.18 g/mol
- IUPAC name
- 1-methoxy-3-(2-nitroimidazol-1-yl)propan-2-ol
- SMILES
- COCC(CN1C=CN=C1[N+](=O)[O-])O
- InChIKey
- OBBCSXFCDPPXOL-UHFFFAOYSA-N
- XLogP
- -0.4
- Polar surface area
- 93.1 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
1,892 papers- Misonidazole neuropathy.Acta neurologica Scandinavica. Supplementum · 1984
- Radiosensitisers.British medical journal · 1980
- Glutathione conjugates of misonidazole.Biochemical and biophysical research communications · 1983
- Kinetics of misonidazole enantiomers.Clinical pharmacology and therapeutics · 1984
- Meta-analytic re-evaluation of misonidazole in the treatment of high grade astrocytoma.Anticancer research · 1998
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 201.075
- Has use
- medication
Show 4 more facts
- canonical SMILES
- COCC(CN1C=CN=C1[N+](=O)[O-])O
- chemical formula
- C₇H₁₁N₃O₄
- subject has role
- radiosensitizer
- Commons category
- Misonidazole
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Misonidazole is a radiosensitizer that was investigated in clinical trials. It was used in these trials for radiation therapy to cause normally resistant hypoxic tumor cells to become sensitive to the treatment.
==See also== Etanidazole
Excerpted from Wikipedia’s “misonidazole” article, available under the CC BY-SA 4.0 licence.