Structure via PubChem · Public domain (PubChem)
etanidazole
Sign in to saveAlso known as N-(2-Hydroxyethyl)-2-nitro-1H-imidazole-1-acetamide, N-(2-Hydroxyethyl)-2-nitroimidazole-1-acetamide, N-(2-Hydroxyethyl)-1-(2-nitro-1-imidazolyl)acetamide
Etanidazole is a nitroimidazole drug that was investigated in clinical trials for its radiosensitizing properties in cancer treatment. Administration of etanidazole results in a decrease of glutathione concentration and inhibits glutathione S-transferase. The result is that tissues become more sensitive to the ionizing radiation.
In the Vinony graph
Within Vinony's link graph, etanidazole is referenced by 6 other articles, and connects out to medication, digital object identifier and chemical formula.
It sits within the topics Chembox image size set, ECHA InfoCard ID from Wikidata and Hydroxyethyl compounds.
Its subject is documented across 6 Wikipedia language editions.
Chemical data
- Formula
- C7H10N4O4
- Molecular weight
- 214.18 g/mol
- IUPAC name
- N-(2-hydroxyethyl)-2-(2-nitroimidazol-1-yl)acetamide
- SMILES
- C1=CN(C(=N1)[N+](=O)[O-])CC(=O)NCCO
- InChIKey
- WCDWBPCFGJXFJZ-UHFFFAOYSA-N
- XLogP
- -1.3
- Polar surface area
- 113 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
329 papers- Pharmacology and clinical investigation of SR-2508 (etanidazole).Cancer treatment and research · 1991
- Radiosensitization of paclitaxel, etanidazole and paclitaxel+etanidazole nanoparticles on hypoxic human tumor cells in vitro.Biomaterials · 2007
- Evaluation of the in vivo radiosensitizing activity of etanidazole using tumor-bearing chick embryo.Journal of radiation research · 2011
- Modification of the aerobic cytotoxicity of etanidazole.International journal of radiation oncology, biology, physics · 1994
- PEG modulated release of etanidazole from implantable PLGA/PDLA discs.Biomaterials · 2002
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 214.07
- Has use
- medication
Show 5 more facts
- chemical formula
- C₇H₁₀N₄O₄
- canonical SMILES
- C1=CN(C(=N1)[N+](=O)[O-])CC(=O)NCCO
- World Health Organisation international non-proprietary name
- etanidazole
- subject has role
- radiosensitizer
- Commons category
- Etanidazole
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Etanidazole is a nitroimidazole drug that was investigated in clinical trials for its radiosensitizing properties in cancer treatment. Administration of etanidazole results in a decrease of glutathione concentration and inhibits glutathione S-transferase. The result is that tissues become more sensitive to the ionizing radiation.
==See also== 18F-EF5, a related nitroimidazole Misonidazole
Excerpted from Wikipedia’s “etanidazole” article, available under the CC BY-SA 4.0 licence.