mitomycins
Sign in to saveAlso known as mitomycin
thumb|right|Chemical structure of mitomycin C The mitomycins are a family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. They include mitomycin A, mitomycin B, and mitomycin C. When the name mitomycin occurs alone, it usually refers to mitomycin C, its international nonproprietary name. Mitomycin C is used as a medicine for treating various disorders associated with the growth and spread of cells.
Research
24,627 papers- Mitomycins.Cancer chemotherapy and biological response modifiers · 1996
- Cytotoxicity, crosslinking and biological activity of three mitomycins.Bioorganic chemistry · 2022
- Mitomycin C.Cancer chemotherapy and biological response modifiers · 1990
- Mitomycin C.Cancer chemotherapy and biological response modifiers · 1992
- Mitomycin C.Cancer chemotherapy and biological response modifiers · 1988
via PubMed
Wikidata facts
Show 3 more facts
- Commons category
- Mitomycins
- MCN code
- 3004.20.91
- stylized name
- mitoMYcin
Sources (2)
via Wikidata · CC0
~4 min read
Article
4 sectionsContents
- Biosynthesis
- Biological effects
- Medicinal uses and research
- References
thumb|right|Chemical structure of mitomycin C The mitomycins are a family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. They include mitomycin A, mitomycin B, and mitomycin C. When the name mitomycin occurs alone, it usually refers to mitomycin C, its international nonproprietary name. Mitomycin C is used as a medicine for treating various disorders associated with the growth and spread of cells.
== Biosynthesis == In general, the biosynthesis of all mitomycins proceeds via combination of 3-amino-5-hydroxybenzoic acid (AHBA), D-glucosamine, and carbamoyl phosphate, to form the mitosane core, followed by specific tailoring steps. The key intermediate, AHBA, is a common precursor to other anticancer drugs, such as rifamycin and ansamycin.