MOCS2

Also known as MCBPE, MOCO1, MOCODB, MPTS, molybdenum cofactor synthesis 2

Molybdenum cofactor synthesis protein 2A and molybdenum cofactor synthesis protein 2B are a pair of proteins that in humans are encoded from the same MOCS2 gene. These two proteins dimerize to form molybdopterin synthase.

Gene data

MOCS2

Name: molybdenum cofactor synthesis 2
Type: protein-coding
Aliases: MCBPE, MOCO1, MOCODB, MOCODB1, MPTS

Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

molybdenum cofactor synthesis 2

Symbol: MOCS2
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:53,094,141-53,113,016
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 32193
exact match: identifiers.org/ncbigene/4338
genomic end: 52405893
genomic start: 52391509
cytogenetic location: 5q11.2

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Article

6 sections

Contents

Function
Gene
Genetic disease
Protein structure
References
Further reading

== Function == Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin and the catalytically active metal molybdenum. MoCo is synthesized from cyclic pyranopterin monophosphate (precursor Z) by the heterodimeric enzyme molybdopterin synthase.