MSLN
Sign in to saveAlso known as MPF, SMRP, mesothelin
Mesothelin, also known as MSLN, is a protein that in humans is encoded by the MSLN gene.
Gene data
MSLN- Name
- mesothelin
- Type
- protein-coding
- Aliases
- MPF, SMRP
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016].
via MyGene.info
Gene · Ensembl
mesothelin
- Symbol
- MSLN
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:760,729-768,866
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- MSLN protein.png
Show 5 more facts
- HomoloGene ID
- 4249
- exact match
- identifiers.org/ncbigene/10232
- genomic end
- 818865
- genomic start
- 760734
- cytogenetic location
- 16p13.3
via Wikidata · CC0
~4 min read
Article
5 sectionsContents
- Function
- Medical applications
- References
- Further reading
- External links
Mesothelin, also known as MSLN, is a protein that in humans is encoded by the MSLN gene.
== Function ==