MT3

Also known as GIF, GIFB, GRIF, ZnMT3, metallothionein 3

Metallothionein-3 (also known as Growth Inhibitory Factor) is a protein that in humans is encoded by the MT3 gene. It is a 68-amino acid peptide (20 of which are cysteine) that is abnormally under-expressed in the brains of patients with Alzheimer's disease. Metallothionein-3 is a member of the metallothionein family of proteins.

Gene data

MT3

Name: metallothionein 3
Type: protein-coding
Position: 56,589,074–56,591,088 (+)
Aliases: GIF, GIFB, GRIF, ZnMT3
Ensembl: ENSG00000087250
RefSeq RNA: NM_005954.4
RefSeq protein: NP_005945.1

This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. This gene family member displays tissue-specific expression, and contains a threonine insert near its N-terminus and a glutamate-rich hexapeptide insert near its C-terminus relative to the proteins encoded by other gene family members. It plays an important role in zinc and copper homeostasis, and is induced under hypoxic conditions. The encoded protein is a growth inhibitory factor, and reduced levels of the protein are observed in the brains of individuals with some metal-linked neurodegenerative disorders such as Alzheimer's disease. [provided by RefSeq, Sep 2017].