neocuproine
Sign in to saveAlso known as DMPHEN, neocuproin, 2,9-dimethylphenanthroline, 2,9-dimethyl-o-phenanthroline
Neocuproine is a heterocyclic organic compound and chelating agent. Phenanthroline ligands were first published in the late 19th century, and the derivatives substituted at the 2 and 9 positions are among the most studied of the modified phenanthrolines.
Research
424 papers- Neocuproine as a Redox-Active Ligand Platform on Iron and Cobalt.Inorganic chemistry · 2019
- Hydrazine Hydrate Accelerates Neocuproine-Copper Complex Generation and Utilization in Alkyne Reduction, a Significant Supplement Method for Catalytic Hydrogenation.The Journal of organic chemistry · 2021
- Neocuproine ablates melanocytes in adult zebrafish.Zebrafish · 2008
- Protein sulfhydration.Methods in enzymology · 2015
- Anticandidal Cu(I) complexes with neocuproine and 1-(4-methoxyphenyl)piperazine based diphenylaminomethylphosphine: Is Cu-diimine moiety a pharmacophore?Journal of inorganic biochemistry · 2023
via PubMed
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Encyclopedic overview
5 sectionsContents
- Synthesis and structure
- Coordination chemistry
- Other metals
- References
- Appendix: NMR Shifts
Neocuproine is a heterocyclic organic compound and chelating agent. Phenanthroline ligands were first published in the late 19th century, and the derivatives substituted at the 2 and 9 positions are among the most studied of the modified phenanthrolines.
==Synthesis and structure== Neocuproine can be prepared by sequential Skraup reactions (Doebner-Miller reaction/condensation) of o-nitroaniline (2-Nitroaniline) with crotonaldehyde diacetate. An alternate synthesis involves the condensation of o-phenylenediamine, m-nitrobenzenesulphonate, and crotonaldehyde diacetate. This method gives higher yields but is less economical. Neocuproine crystallizes as a dihydrate and a hemihydrate. [[File:NIPHOJ.png|thumb|structure of [NiCl2(neocuproine)]2.|260px|left]]
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