Structure via PubChem · Public domain (PubChem)
neostigmine
Sign in to saveAlso known as [3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium, [3-(dimethylcarbamoyloxy)phenyl]-trimethyl-azanium, [3-[dimethylamino(oxo)methoxy]phenyl]-trimethylammonium, [3-(dimethylcarbamoyloxy)phenyl]-trimethyl-ammonium, 3-trimethylammoniumphenyl N,N-dimethylcarbamate, (m-hydroxyphenyl)trimethylammonium dimethylcarbamate, m-trimethylammoniumphenyldimethylcarbamate
Neostigmine, sold under the brand name Bloxiverz, among others, is a medication used to treat myasthenia gravis, Ogilvie syndrome, and urinary retention without the presence of a blockage. It is also used in anaesthesia to end the effects of non-depolarising neuromuscular blocking medication. It is given by injection either into a vein, muscle, or under the skin. After injection effects are generally greatest within 30 minutes and last up to 4 hours.
Chemical data
- Formula
- C12H19N2O2+
- Molecular weight
- 223.29 g/mol
- IUPAC name
- [3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium
- SMILES
- CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C
- InChIKey
- ALWKGYPQUAPLQC-UHFFFAOYSA-N
- XLogP
- 1.5
- Polar surface area
- 29.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 1
via PubChem
Research
6,833 papers- The clinical utility of neostigmine administration in the diagnosis of acquired myasthenia gravis.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) · 2021
- Neostigmine Hyperinflation.Journal of pharmacy practice · 2018
- Intravenous neostigmine for postoperative acute colonic pseudo-obstruction.The Annals of pharmacotherapy · 2012
- Use of neostigmine in the management of acute postoperative pain and labour pain: a review.CNS drugs · 2006
- Neostigmine (prostigmine).Journal of the American Medical Women's Association · 1947
via PubMed
~7 min read
Encyclopedic overview
8 sectionsContents
- Medical uses
- Side effects
- Pharmacology
- Chemistry
- Spectral data
- History
- References
- External links
{{Drugbox | Verifiedfields = changed | verifiedrevid = 462259406 | image = Neostigmine.svg | image_class = skin-invert-image | image2 = Neostigmine ball-and-stick.png | image_class2 = bg-transparent
| tradename = Bloxiverz, Prostigmin, Vagostigmin, others | Drugs.com = | DailyMedID = Neostigmine | pregnancy_AU = B2 | pregnancy_AU_comment = | pregnancy_category= | routes_of_administration = Intramuscular, intravenous, subcutaneous, by mouth | class = Cholinesterase inhibitor | ATC_prefix = N07 | ATC_suffix = AA01 | ATC_supplemental =
Excerpted from Wikipedia’s “neostigmine” article, available under the CC BY-SA 4.0 licence.