neurulation
Sign in to saveNeurulation refers to the folding process in vertebrate embryos, which includes the transformation of the neural plate into the neural tube. The embryo at this stage is termed the neurula.
Key facts
- Anatomy.Name
- Neurulation
- Anatomy.Image
- 2912_Neurulation-02.jpg
- Anatomy.Caption
- Transverse sections that show the progression of the neural plate to the neural groove from bottom to top
- Anatomy.Width
- 400
via Wikipedia infobox
Research
2,093 papers- Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture.Cell · 2023
- Embryo model completes gastrulation to neurulation and organogenesis.Nature · 2022
- Stem cell-derived models of spinal neurulation.Emerging topics in life sciences · 2023
- Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development.Cell stem cell · 2022
- Neurulation: coming to closure.Trends in neurosciences · 1997
via PubMed
~13 min read
Article
14 sectionsContents
- Primary neural induction
- Shape change
- Folding
- Patterning
- Complexities of the model
- Secondary neurulation
- Early brain development
- Non-neural ectoderm tissue
- Neural crest cells
- Neural tube defects
- See also
- References
- Further reading
- External links
Neurulation refers to the folding process in vertebrate embryos, which includes the transformation of the neural plate into the neural tube. The embryo at this stage is termed the neurula.
The process begins when the notochord induces the formation of the central nervous system (CNS) by signaling the ectoderm germ layer above it to form the thick and flat neural plate. The neural plate folds in upon itself to form the neural tube, which will later differentiate into the spinal cord and the brain, eventually forming the central nervous system. Computer simulations found that cell wedging and differential proliferation are sufficient for mammalian neurulation.