Nicastrin
Sign in to saveAlso known as uniprot:Q92542, NCSTN, anterior pharynx-defective 2
Nicastrin, also known as NCSTN, is a protein that in humans is encoded by the NCSTN gene.
Protein · UniProt
Nicastrin
- Gene
- NCSTN
- Organism
- Homo sapiens (Human)
- Length
- 709 aa
- Molecular mass
- 78,411 Da
- Evidence
- 1: Evidence at protein level
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels
Swiss-Prot (reviewed) · via UniProt
~1 min read
Article
5 sectionsContents
- Function
- History
- Interactions
- References
- External links
Nicastrin, also known as NCSTN, is a protein that in humans is encoded by the NCSTN gene.
==Function== Nicastrin (abbreviated NCT) is a protein that is part of the gamma secretase protein complex, which is one of the proteases involved in processing amyloid precursor protein (APP) to the short Alzheimer's disease-associated peptide amyloid beta. The other proteins in the complex are PSEN1 (presenilin-1), which is the catalytically active component of the complex, APH-1 (anterior pharynx-defective 1), and PEN-2 (presenilin enhancer 2). Nicastrin itself is not catalytically active, but instead promotes the maturation and proper trafficking of the other proteins in the complex, all of which undergo significant post-translational modification before becoming active in the cell. Nicastrin has also been identified as a regulator of neprilysin, an enzyme involved in the degradation of amyloid beta fragment.