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nikethamide
Sign in to saveAlso known as Niquetamida
Nikethamide is a stimulant which mainly affects the respiratory cycle. Widely known by its former trade name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overdoses, before the advent of endotracheal intubation and positive-pressure lung expansion. It is no longer commonly considered to be of value for such purposes.
Chemical data
- Formula
- C10H14N2O
- Molecular weight
- 178.23 g/mol
- IUPAC name
- N,N-diethylpyridine-3-carboxamide
- SMILES
- CCN(CC)C(=O)C1=CN=CC=C1
- InChIKey
- NCYVXEGFNDZQCU-UHFFFAOYSA-N
- XLogP
- 0.3
- Polar surface area
- 33.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Research
488 papers- Nikethamide.The Indian physician · 1945
- Nikethamide for hiccough.Anaesthesia · 1979
- Potentiation of cathinone by caffeine and nikethamide.Pharmacology, biochemistry, and behavior · 1989
- Preventive and therapeutic effects of magnesium sulfate on nikethamide-induced seizures: Implications for COVID-19 treatment.World journal of methodology · 2025
- Determination of nikethamide by micellar electrokinetic chromatography.Biomedical chromatography : BMC · 2019
via PubMed
Wikidata facts
- Subclass of
- pyridine alkaloid
- Has part
- carbon
- Mass
- 178.111
Show 6 more facts
- canonical SMILES
- CCN(CC)C(=O)C1=CN=CC=C1
- chemical formula
- C₁₀H₁₄N₂O
- density
- 1.06
- found in taxon
- Corydalis
- has characteristic
- bitterness
- Commons category
- Nikethamide
Sources (2)
via Wikidata · CC0
~3 min read
Encyclopedic overview
8 sectionsContents
- Uses
- Available forms
- Contraindications
- Society and culture
- Use in sports
- See also
- References
- External links
Nikethamide is a stimulant which mainly affects the respiratory cycle. Widely known by its former trade name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overdoses, before the advent of endotracheal intubation and positive-pressure lung expansion. It is no longer commonly considered to be of value for such purposes.
In alternate terminology, it is known as nicotinic acid diethylamide, which meaningfully emphasizes its laboratory origins, and of which its common name is derived as a blend.
Excerpted from Wikipedia’s “nikethamide” article, available under the CC BY-SA 4.0 licence.