NNMT
Sign in to saveAlso known as nicotinamide N-methyltransferase
Nicotinamide N-methyltransferase (NNMT) is an enzyme that in humans is encoded by the NNMT gene. NNMT catalyzes the methylation of nicotinamide and similar compounds using the methyl donor S-adenosyl methionine (SAM-e) to produce S-adenosyl-L-homocysteine (SAH) and 1-methylnicotinamide.
Gene data
NNMT- Name
- nicotinamide N-methyltransferase
- Type
- protein-coding
N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
nicotinamide N-methyltransferase
- Symbol
- NNMT
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:114,257,765-114,360,039
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein NNMT PDB 2iip.png
Show 5 more facts
- HomoloGene ID
- 4496
- exact match
- identifiers.org/ncbigene/4837
- genomic start
- 114128509
- cytogenetic location
- 11q23.2
- genomic end
- 114184007
Sources (4)
via Wikidata · CC0
~2 min read
Article
4 sectionsContents
- Function
- Clinical significance
- References
- Further reading
Nicotinamide N-methyltransferase (NNMT) is an enzyme that in humans is encoded by the NNMT gene. NNMT catalyzes the methylation of nicotinamide and similar compounds using the methyl donor S-adenosyl methionine (SAM-e) to produce S-adenosyl-L-homocysteine (SAH) and 1-methylnicotinamide.
==Function== Methylation of nicotinamide by NNMT and SAM-e is the major pathway for degradation of nicotinamide leading to excretion in the urine.