NOL12
Sign in to saveAlso known as Nop25, dJ37E16.7, nucleolar protein 12
Nucleolar protein 12 is a protein that in humans is encoded by the NOL12 gene. Human NOL12 has been shown to localize in the nucleolus and regulate nucleolar structure and homeostasis by maintaining the levels of multi-functional fibrillarin and nucleolin proteins. Its deficiency leads to p53 activation resulting in G2 arrest of cell. Nol12 or hNol12 drives p53 induced cell senescence suggesting its important role in aging. Human Nol12 is also required for ribosome maturation and genome integrity.
In the Vinony graph
Vinony's link graph records 2 inbound references to NOL12, and connects out to Q180686, human chromosome 22 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 22.
Vinony links it to 6 Wikipedia language editions.
Gene data
NOL12- Name
- nucleolar protein 12
- Type
- protein-coding
- Position
- 37,681,673–37,693,476 (+)
- Aliases
- Nop25, VITO, dJ37E16.7
- Ensembl
- ENSG00000273899
- RefSeq RNA
- NM_024313.3
- RefSeq protein
- NP_077289.1
Enables identical protein binding activity. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
nucleolar protein 12
- Symbol
- NOL12
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:37,681,673-37,693,476
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 32577
- exact match
- identifiers.org/ncbigene/79159
- genomic end
- 37693476
- genomic start
- 38077680
- cytogenetic location
- 22q13.1
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Nol12 Family
- References
- Further reading
Nucleolar protein 12 is a protein that in humans is encoded by the NOL12 gene. Human NOL12 has been shown to localize in the nucleolus and regulate nucleolar structure and homeostasis by maintaining the levels of multi-functional fibrillarin and nucleolin proteins. Its deficiency leads to p53 activation resulting in G2 arrest of cell. Nol12 or hNol12 drives p53 induced cell senescence suggesting its important role in aging. Human Nol12 is also required for ribosome maturation and genome integrity.
== Nol12 Family ==
Excerpted from Wikipedia’s “NOL12” article, available under the CC BY-SA 4.0 licence.