NSL1
Sign in to saveAlso known as C1orf48, MIS14, DC8, NSL1, MIS12 kinetochore complex component, NSL1 component of MIS12 kinetochore complex
Kinetochore-associated protein NSL1 homolog is a protein that in humans is encoded by the NSL1 gene.
Gene data
NSL1- Name
- NSL1 component of MIS12 kinetochore complex
- Type
- protein-coding
- Position
- 212,726,153–212,791,799 (−)
- Aliases
- C1orf48, DC8, MIS14
- Ensembl
- ENSG00000117697
- RefSeq RNA
- NM_001042549.2, NM_001297736.2, NM_001297737.2, NM_001297739.2, NM_015471.4
- RefSeq protein
- NP_001036014.1, NP_001284665.1, NP_001284666.1, NP_001284668.1, NP_056286.3
This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X. [provided by RefSeq, Jul 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
NSL1 component of MIS12 kinetochore complex
- Symbol
- NSL1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:212,726,153-212,791,799
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 22898
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/25936
- genomic end
- 212965124
- genomic start
- 212899495
- chromosome
- human chromosome 1
- cytogenetic location
- 1q32.3
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Kinetochore-associated protein NSL1 homolog is a protein that in humans is encoded by the NSL1 gene.
This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene.
Excerpted from Wikipedia’s “NSL1” article, available under the CC BY-SA 4.0 licence.