olaflur

Olaflur (INN, or amine fluoride 297) is a fluoride-containing substance that is an ingredient of toothpastes and solutions for the prevention of dental caries. It has been in use since 1966. Especially in combination with dectaflur, it is also used in the form of gels for the treatment of early stages of caries, sensitive teeth, and by dentists for the refluoridation of damaged tooth enamel.

Chemical data

Formula: C27H60F2N2O3
Molecular weight: 498.8 g/mol
IUPAC name: 2-[3-[bis(2-hydroxyethyl)amino]propyl-octadecylamino]ethanol;dihydrofluoride

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule

via ChEMBL · EBI

Research

152 papers

Allergic contact cheilitis caused by olaflur in toothpaste.Contact dermatitis · 2017
Effects of two fluoridation measures on erosion progression in human enamel and dentine in situ.Caries research · 2004
Effectiveness of two fluoridation measures on erosion progression in human enamel and dentine in vitro.Caries research · 2001
Salivary Flow Rate During Toothbrushing.Oral health & preventive dentistry · 2022
Evaluation of Local Tolerance of Structurally Different Olaflur Compounds.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2026

via PubMed

Wikidata facts

Mass: 498.457

Show 3 more facts

chemical formula: C₂₇H₆₀F₂N₂O₃
canonical SMILES: CCCCCCCCCCCCCCCCCCN(CCCN(CCO)CCO)CCO.F.F
defined daily dose: 1.1

Sources (2)

via Wikidata · CC0

~4 min read

Article

6 sections

Contents

Overdosage
Interactions
Chemistry and mechanism of action
Synthesis
See also
References

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