osteoid
Sign in to saveIn histology, osteoid is the unmineralized, organic portion of the bone matrix that forms prior to the maturation of bone tissue. Osteoblasts begin the process of forming bone tissue by secreting the osteoid as several specific proteins. The osteoid and its adjacent bone cells have developed into new bone tissue when it becomes mineralized.
Key facts
- Anatomy.Name
- Osteoid
- Anatomy.Image
- Active osteoblasts.jpg
- Anatomy.Caption
- Light micrograph of osteoid, containing two osteocytes, being synthesized by osteoblasts.
- Anatomy.Width
- 320
via Wikipedia infobox
Wikidata facts
Show 1 more fact
- name
- остеоид
Sources (3)
via Wikidata · CC0
~9 min read
Article
16 sectionsContents
- Composition
- Collagen fibers
- Ground substance
- Formation and secretion
- Mineralization
- Mechanism of mineralization
- Clinical significance
- Disorders of osteoid mineralization
- Osteoid in bone tumors
- Role in bone remodeling
- Biochemical markers
- Physiology
- Disorders
- See also
- References
- External links
In histology, osteoid is the unmineralized, organic portion of the bone matrix that forms prior to the maturation of bone tissue. Osteoblasts begin the process of forming bone tissue by secreting the osteoid as several specific proteins. The osteoid and its adjacent bone cells have developed into new bone tissue when it becomes mineralized.
Osteoid makes up about fifty percent of bone volume and forty percent of bone weight. It is composed of fibers and ground substance. The predominant type of fiber is type I collagen and comprises ninety percent of the osteoid. The ground substance is mostly made up of chondroitin sulfate and osteocalcin. Osteoblasts synthesize and secrete osteoid as an unmineralized organic matrix, and when the osteoid becomes mineralized through deposition of calcium salts, it transforms into mature bone tissue.