PCSK7

Also known as LPC, PC7, PC8, SPC7, proprotein convertase subtilisin/kexin type 7

Proprotein convertase subtilisin/kexin type 7 is an enzyme that in humans is encoded by the PCSK7 gene.

Gene data

PCSK7

Name: proprotein convertase subtilisin/kexin type 7
Type: protein-coding
Position: 117,204,337–117,232,528 (−)
Aliases: LPC, PC7, PC8, SPC7
Ensembl: ENSG00000160613
RefSeq RNA: NM_004716.4, XM_006718940.5, XM_047427861.1, XM_047427862.1, XM_047427863.1
RefSeq protein: NP_004707.2, XP_006719003.1, XP_047283817.1, XP_047283818.1, XP_047283819.1

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Feb 2014].

Gene Ontology

Biological process

proteolysis protein processing protein processing peptide hormone processing

Molecular function

serine-type endopeptidase activity serine-type endopeptidase activity serine-type endopeptidase activity protein binding peptidase activity serine-type peptidase activity

Cellular component

Golgi membrane Golgi membrane Golgi membrane cytoplasm Golgi apparatus trans-Golgi network endomembrane system

Pathways

Cell-Cell communication Adherens junctions interactions Cell-cell junction organization Cell junction organization Regulation of Homotypic Cell-Cell Adhesion Regulation of CDH1 Expression and Function Regulation of Expression and Function of Type I Classical Cadherins Regulation of CDH1 posttranslational processing and trafficking to plasma membrane

via MyGene.info

Gene · Ensembl

proprotein convertase subtilisin/kexin type 7

Symbol: PCSK7
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:117,202,588-117,232,628
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 37955
exact match: identifiers.org/ncbigene/9159
genomic end: 117103241
genomic start: 117075053
cytogenetic location: 11q23.3

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Proprotein convertase subtilisin/kexin type 7 is an enzyme that in humans is encoded by the PCSK7 gene.

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140.