pellagra

Also known as Niacin deficiency, Niacin-tryptophan deficiency, Pellagra (disorder)

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Key facts

Medical condition (new).name: Pellagra
Medical condition (new).image: Pellagra2.jpg
Medical condition (new).caption: The skin features of pellagra including peeling, redness, scaling, and thickening of sun-exposed areas.
Medical condition (new).field: Dermatology
Medical condition (new).symptoms: Inflammation of the skin, diarrhea, dementia, sores in the mouth
Medical condition (new).types: Primary, secondary
Medical condition (new).causes: Not enough niacin
Medical condition (new).diagnosis: Based on symptoms
Medical condition (new).differential: Kwashiorkor, pemphigus, photodermatitis, porphyria
Medical condition (new).prevention: Consuming Niacin
Medical condition (new).treatment: Nicotinic acid or nicotinamide supplementation.
Medical condition (new).prognosis: Good (with treatment), death in ~ 5 years (without treatment)
Medical condition (new).frequency: Rare (developed world), relatively common (developing world)

via Wikipedia infobox

Research

1,729 papers

via PubMed

Wikidata facts

Image: Pellagra NIH.jpg

Show 4 more facts

exact match: www.orpha.net/ORDO/Orphanet_97352
ICD-9-CM: 265.2
Commons category: Pellagra
ICPC 2 ID: T91

Sources (6)

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~20 min read

Article

12 sections

Contents

Etymology
Signs and symptoms
Pathophysiology
Treatment
Epidemiology
History
United States
Corn processing
In popular culture
References
Further reading
External links

Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B3). Symptoms include inflamed skin, diarrhea, dementia, and sores in the mouth. Areas of the skin exposed to friction and radiation are typically affected first. Over time, affected skin may become darker, stiffen, peel, or bleed.

The two main types of pellagra are primary and secondary. Primary pellagra is due to a diet that does not contain enough niacin and tryptophan. Secondary pellagra is due to a poor ability to use the niacin within the diet. This can occur as a result of alcoholism, long-term diarrhea, carcinoid syndrome, Hartnup disease, and a number of medications such as isoniazid. Diagnosis is typically based on symptoms and may be assisted by urine testing.