Structure via PubChem · Public domain (PubChem)
phosalone
Sign in to saveAlso known as Agria 1060 A, S-[(6-chloro-2-oxo-1,3-benzoxazol-3(2H)-yl)methyl] O,O-diethyl dithiophosphate, Phosphorodithioic acid, S-((6-chloro-2-oxo-3(2H)-benzoxazolyl)methyl) O,O-diethyl ester, 3-[O,O-(Diethyldithiophosphoryl)methyl]-6-chlorobenzoxazolinone
Phosalone is an organophosphate chemical commonly used as an insecticide and acaricide. It is developed by Rhône-Poulenc in France but EU eliminated it from pesticide registration in December 2006.
Chemical data
- Formula
- C12H15ClNO4PS2
- Molecular weight
- 367.8 g/mol
- IUPAC name
- 6-chloro-3-(diethoxyphosphinothioylsulfanylmethyl)-1,3-benzoxazol-2-one
- SMILES
- CCOP(=S)(OCC)SCN1C2=C(C=C(C=C2)Cl)OC1=O
- InChIKey
- IOUNQDKNJZEDEP-UHFFFAOYSA-N
- XLogP
- 4.4
- Polar surface area
- 105 Ų
- H-bond donors
- 0
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
218 papers- Degradation of phosalone by silver ion catalytic hydrolysis.Toxicology mechanisms and methods · 2021
- Phosalone-induced inflammation and oxidative stress in the colon: Evaluation and treatment.World journal of gastroenterology · 2016
- Effects of phosalone consumption via feeding with or without sodium bentonite on performance, blood metabolites and its transition to milk of Iranian Baluchi sheep.Journal of animal science and technology · 2017
- Effects of phosalone plant pesticide on sperm parameters and sexual hormone levels in Wistar rats: An experimental study.International journal of reproductive biomedicine · 2020
- Side effects of chlorantraniliprole, phosalone and spinosad on the egg parasitoid, Trichogramma brassicae.Ecotoxicology (London, England) · 2020
via PubMed
Wikidata facts
- Mass
- 366.987
- Has use
- insecticide
Show 5 more facts
- chemical formula
- C₁₂H₁₅ClNO₄PS₂
- canonical SMILES
- CCOP(=S)(OCC)SCN1C2=C(C=C(C=C2)Cl)OC1=O
- subject has role
- acetylcholinesterase inhibitor
- found in taxon
- Sorangium cellulosum
- Commons category
- Phosalone
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- External links
Phosalone is an organophosphate chemical commonly used as an insecticide and acaricide. It is developed by Rhône-Poulenc in France but EU eliminated it from pesticide registration in December 2006.
The median lethal dose of oral exposure in rat is 85 mg/kg and that of dermal is 390 mg/kg.。It is a weak acetylcholinesterase inhibitor. It is taken by not only oral and inhalation but skin and it causes toxic symptoms peculiar to organophosphorus compounds such as miosis, hypersalivation, hyperhidrosis, chest pressure, pulmonary edema and fecal incontinence. It is flammable and decomposes to toxic gases such as phosphorus oxides, sulfur oxides and nitrogen oxides. It is harmful especially to water creatures.
Excerpted from Wikipedia’s “phosalone” article, available under the CC BY-SA 4.0 licence.
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via Wikidata sitelinks · CC0