POT1
Sign in to saveAlso known as CMM10, HPOT1, GLM9, protection of telomeres 1
Protection of telomeres protein 1 is a protein that in humans is encoded by the POT1 gene.
Gene data
POT1- Name
- protection of telomeres 1
- Type
- protein-coding
- Position
- 124,822,386–124,929,959 (−)
- Aliases
- CMM10, CRMCC3, GLM9, HPOT1, PFBMFT8, TPDS3
- Ensembl
- ENSG00000128513
- RefSeq RNA
- NM_001042594.2, NM_015450.3, NR_003102.2, NR_003103.2, NR_003104.2
- RefSeq protein
- NP_001036059.1, NP_056265.2
This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
protection of telomeres 1
- Symbol
- POT1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:124,822,386-124,929,983
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein POT1 PDB 1xjv.png
Show 5 more facts
- HomoloGene ID
- 32263
- exact match
- identifiers.org/ncbigene/25913
- genomic end
- 124570037
- genomic start
- 124462440
- cytogenetic location
- 7q31.33
via Wikidata · CC0
~2 min read
Article
6 sectionsContents
- Function
- Interactions
- Pathology
- References
- Further reading
- External links
Protection of telomeres protein 1 is a protein that in humans is encoded by the POT1 gene.
== Function ==