Also known as Epoc-1, OCT-11, OCT11, OTF-11, PLA-1, PLA1, Skn-1a, POU class 2 homeobox 3
POU domain, class 2, transcription factor 3 is a protein that in humans is encoded by the POU2F3 gene.
This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].
Biological process
~1 min read
POU domain, class 2, transcription factor 3 is a protein that in humans is encoded by the POU2F3 gene.
== References ==
Molecular function
via MyGene.info
via Wikidata · CC0
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).