pralidoxime
Also known as 2-PAM
Pralidoxime (2-pyridine aldoxime methyl chloride) or 2-PAM, usually as the chloride or iodide salts, belongs to a family of compounds called oximes that bind to organophosphate-inactivated acetylcholinesterase. It is used to treat organophosphate poisoning in conjunction with atropine and either diazepam or midazolam. It is a white solid.
Chemical data
- Formula
- C7H9N2O+
- Molecular weight
- 137.16 g/mol
- IUPAC name
- (NZ)-N-[(1-methylpyridin-1-ium-2-yl)methylidene]hydroxylamine
- SMILES
- C[N+]1=CC=CC=C1/C=N\O
- InChIKey
- JBKPUQTUERUYQE-UHFFFAOYSA-O
- XLogP
- 1
- Polar surface area
- 36.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 1
via PubChem
Research
1,679 papersArticle
8 sectionsContents
- Chemical synthesis
- Mechanism of action
- Dosage
- Interactions
- Contraindications
- See also
- References
- External links
Pralidoxime (2-pyridine aldoxime methyl chloride) or 2-PAM, usually as the chloride or iodide salts, belongs to a family of compounds called oximes that bind to organophosphate-inactivated acetylcholinesterase. It is used to treat organophosphate poisoning in conjunction with atropine and either diazepam or midazolam. It is a white solid.
==Chemical synthesis== Pralidoxime, 2-pyridinaldoxime methylchloride, is prepared by treating pyridine-2-carboxaldehyde with hydroxylamine. The resulting pyridine-2-aldoxime is alkylated with methyl iodide giving pralidoxime as the iodide salt. 500px|center