PSMF1

Name

proteasome inhibitor subunit 1

Type

protein-coding

Position

1,113,240–1,192,353 (+)

Aliases

PI31

Ensembl

ENSG00000125818

RefSeq RNA

NM_001323407.2, NM_001323408.2, NM_001323409.2, NM_001323410.2, NM_006814.5

RefSeq protein

NP_001310336.1, NP_001310337.1, NP_001310338.1, NP_001310339.1, NP_006805.2

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

proteasome inhibitor subunit 1

Symbol

PSMF1

Biotype

Protein coding

Organism

Homo sapiens

Location

20:1,113,240-1,192,353

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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