QRFP

Also known as 26RFa, P518, pyroglutamylated RFamide peptide

RF(Arg-Phe)amide family 26 amino acid peptide, also known as P518, is a human protein.

Gene data

QRFP

Name: pyroglutamylated RFamide peptide
Type: protein-coding
Position: 130,892,707–130,896,812 (−)
Aliases: 26RFa, P518
Ensembl: ENSG00000188710
RefSeq RNA: NM_198180.3
RefSeq protein: NP_937823.1

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. The encoded products are members of the RFamide family of neuropeptides, characterized by their common protein C-terminus consisting of an arginine (R) and an amidated phenylalanine (F). These products include the neuropeptides 26RFa and the N-terminally extended form, 43RFa. Both of these neuropeptides bind to the pyroglutamylated RFamide peptide receptor (QRFPR) and may regulate blood pressure, reproduction and food intake in rodents. [provided by RefSeq, Jul 2015].

Gene Ontology

Biological process

neuropeptide signaling pathway neuropeptide signaling pathway grooming behavior locomotory behavior locomotory behavior locomotory behavior positive regulation of blood pressure positive regulation of blood pressure

Molecular function

G protein-coupled receptor binding signaling receptor binding neuropeptide hormone activity neuropeptide hormone activity orexigenic neuropeptide QRFP receptor binding orexigenic neuropeptide QRFP receptor binding orexigenic neuropeptide QRFP receptor binding

Cellular component

extracellular region extracellular region

Pathways

Signal Transduction Signaling by GPCR Class A/1 (Rhodopsin-like receptors)Peptide ligand-binding receptors GPCR downstream signalling Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events GPCR ligand binding

via MyGene.info

Gene · Ensembl

pyroglutamylated RFamide peptide

Symbol: QRFP
Biotype: Protein coding
Organism: Homo sapiens
Location: 9:130,892,707-130,896,812
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 52341
exact match: identifiers.org/ncbigene/347148
genomic end: 133769225
genomic start: 130892707
cytogenetic location: 9q34.12

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Further reading

RF(Arg-Phe)amide family 26 amino acid peptide, also known as P518, is a human protein.

The 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain. The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.