QRFP

Also known as 26RFa, P518, pyroglutamylated RFamide peptide

RF(Arg-Phe)amide family 26 amino acid peptide, also known as P518, is a human protein.

Gene data

QRFP

Name: pyroglutamylated RFamide peptide
Type: protein-coding
Position: 130,892,707–130,896,812 (−)
Aliases: 26RFa, P518
Ensembl: ENSG00000188710
RefSeq RNA: NM_198180.3
RefSeq protein: NP_937823.1

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. The encoded products are members of the RFamide family of neuropeptides, characterized by their common protein C-terminus consisting of an arginine (R) and an amidated phenylalanine (F). These products include the neuropeptides 26RFa and the N-terminally extended form, 43RFa. Both of these neuropeptides bind to the pyroglutamylated RFamide peptide receptor (QRFPR) and may regulate blood pressure, reproduction and food intake in rodents. [provided by RefSeq, Jul 2015].

Gene Ontology

Biological process

neuropeptide signaling pathway neuropeptide signaling pathway

Article

3 sections

Contents

References
External links
Further reading

RF(Arg-Phe)amide family 26 amino acid peptide, also known as P518, is a human protein.

The 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain. The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.