RAMP1

Also known as entrez:10267, receptor activity modifying protein 1

Receptor activity modifying protein 1 is a protein that in humans is encoded by the RAMP1 gene.

Gene data

RAMP1

Name: receptor activity modifying protein 1
Type: protein-coding
Position: 237,858,893–237,923,438 (+)
Ensembl: ENSG00000132329
RefSeq RNA: NM_001308353.2, NM_005855.4, XM_017003152.3, XM_017003153.3, XM_017003156.3
RefSeq protein: NP_001295282.1, NP_005846.1, XP_016858641.1, XP_016858642.1, XP_016858645.1

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].

Pathways

Vascular smooth muscle contraction - Homo sapiens (human)Signal Transduction Signaling by GPCR Class B/2 (Secretin family receptors)GPCR downstream signalling G alpha (s) signalling events Calcitonin-like ligand receptors GPCR ligand binding Endothelin Pathways Myometrial relaxation and contraction pathways

via MyGene.info

Gene · Ensembl

receptor activity modifying protein 1

Symbol: RAMP1
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:237,858,893-237,923,438
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

4 sections

Contents

See also
References
Further reading
External links

Receptor activity modifying protein 1 is a protein that in humans is encoded by the RAMP1 gene.

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CALCRL) to the plasma membrane. CALCRL, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In combination with the RAMP1 protein, CALCRL functions as the CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. The RAMP1 protein can also interact with the calcitonin receptor (CT) protein, where heteromerisation of RAMP1 with CT converts CT from a calcitonin receptor to the amylin receptor AMY1

Excerpted from Wikipedia’s “RAMP1” article, available under the CC BY-SA 4.0 licence.